False-positive results in mammographic screening for breast cancer in Europe: a literature review and survey of service screening programmes.
نویسندگان
چکیده
OBJECTIVE To estimate the cumulative risk of a false-positive screening result in European mammographic screening programmes, and examine the rates and procedures of further assessment. METHODS A literature review was conducted to identify studies of the cumulative risk of a false-positive result in European screening programmes (390,000 women). We then examined aggregate data, cross-sectional information about further assessment procedures among women with positive results in 20 mammographic screening programmes from 17 countries (1.7 million initial screens, 5.9 million subsequent screens), collected by the European Network for Information on Cancer project (EUNICE). RESULTS The estimated cumulative risk of a false-positive screening result in women aged 50-69 undergoing 10 biennial screening tests varied from 8% to 21% in the three studies examined (pooled estimate 19.7%). The cumulative risk of an invasive procedure with benign outcome ranged from 1.8% to 6.3% (pooled estimate 2.9%). The risk of undergoing surgical intervention with benign outcome was 0.9% (one study only). From the EUNICE project, the proportions of all screening examinations in the programmes resulting in needle biopsy were 2.2% and 1.1% for initial and subsequent screens, respectively, though the rates differed between countries; the corresponding rates of surgical interventions among women without breast cancer were 0.19% and 0.07%. CONCLUSION The specific investigative procedures following a recall should be considered when examining the cumulative risk of a false-positive screening result. Most women with a positive screening test undergo a non-invasive assessment procedure. Only a small proportion of recalled women undergo needle biopsy, and even fewer undergo surgical intervention.
منابع مشابه
Overdiagnosis in mammographic screening for breast cancer in Europe: a literature review.
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متن کاملSummary of the evidence of breast cancer service screening outcomes in Europe and first estimate of the benefit and harm balance sheet
Accepted for publication 13 June 2012 . . . . . . . . . . . . . . . . . . . Objectives To construct a European ‘balance sheet’ of key outcomes of population-based mammographic breast cancer screening, to inform policy-makers, stakeholders and invited women. Methods From the studies reviewed, the primary benefit of screening, breast cancer mortality reduction, was compared with the main harms, o...
متن کاملSummary of the evidence of breast cancer service screening outcomes in Europe and first estimate of the benefit and harm balance sheet.
OBJECTIVES To construct a European 'balance sheet' of key outcomes of population-based mammographic breast cancer screening, to inform policy-makers, stakeholders and invited women. METHODS From the studies reviewed, the primary benefit of screening, breast cancer mortality reduction, was compared with the main harms, over-diagnosis and false-positive screening results (FPRs). RESULTS Poole...
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ورودعنوان ژورنال:
- Journal of medical screening
دوره 19 Suppl 1 شماره
صفحات -
تاریخ انتشار 2012